The ever-increasing number of people using the internet has drastically changed how clinical trials are promoted to patients. Today, clinical trial sponsors and companies working on their behalf can put ads directly in front of relevant people, to inform and educate them about a trial. In orphan drug R&D, where patient recruitment is a constant challenge, digital advertising is one of the best ways of reaching the relevant niche groups of people affected. So how can sponsors best utilize digital advertising channels to help shorten recruitment timelines, and what rules and regulations do they need to keep in mind?